The Reds sit top of the pile after four rounds of the new season, winning all of their games despite making no signings in the summer. They secured a comfortable 3-0 victory away to Burnley before the international break, Roberto Firmino and Sadio Mane getting on the scoresheet.
Steve Bruces recruits have risen to 14th place following a shaky start to the year. A hard-fought triumph at Tottenham Hotspur got their season on track, with a 1-1 draw with Watford taking them to four points.
Heres our preview of the encounter.
Where to Watch
When is Kick Off?
Saturday 14 September
What Time is Kick Off?
Where is it Played?
TV Channel/Live Stream?
BT Sport 1
Where to Buy Tickets
Tickets for the game are, as ever, available on both teams official club websites, though membership is required in order to purchase. In terms of resale, both teams provide the option to make season tickets available for others to use, if a supporter is unable to attend the game themselves.
Liverpool midfielder Naby Keita is in line for a return to the first-team following a hip problem, though he will face a late fitness test.
Jurgen Klopp will definitely be without goalkeeper Alisson Becker and reserve right-back Nathaniel Clyne. The Brazilian is still recovering from a calf strain, whilst the Englishman will be sidelined until the turn of the year with a serious knee injury.
The Magpies have seven senior players unavailable. Midfield trio Matt Ritchie, Jack Colback and Allan Saint-Maxim are all ruled out, with DeAndre Yedlin and Florian Lejeune also missing.
Two forwards are carrying injuries in Andy Carroll and Dwight Gayle. The former could return before October, though his counterpart has been struggling with a heel issue since pre-season.
Adrian; Alexander-Arnold, Matip, van Dijk, Robertson; Fabinho, Henderson, Wijnaldum; Salah, Mane, Firmino.
Dubravka; Krafth, Schar, Lascelles, Dummett, Willems; Almiron, Hayden, Longstaff, Atsu; Joelinton.
Head to Head Record
This will be the 178th meeting between the two clubs, the Merseysiders having the better of it with 85 wins compared to the visitors 50.
The last time Newcastle defeated the Reds was December 2015, the northerners losing three and drawing two since then.
Their most recent clash came as Liverpool tried to wrestle the Premier League title from Manchester City in May, Klopps men earning a 3-2 victory courtesy of newfound hero Divock Origi.
Virgil van Dijk and Mo Salah exchanged goals with Christian Atsu and the recently departed Salomon Rondon at St. James Park to set up a tense finale, the Belgian striker stealing the points in the closing stages with a towering header.
The league leaders have been electric in most of their games this term, shredding Arsenal and Burnley in their last two matches.
Mane and Firmino have been particularly impressive up front, whilst Joel Matip has stepped up and forged a solid partnership with Van Dijk in the heart of defence.
A testing beginning to the campaign increased the pressure on Bruce, but he has since got a tune out of his squad and collected an excellent victory away to Spurs to temporarily silence his doubters.
However, they are still without a win on home turf after the stalemate with the Hornets and a penalty-shootout exit in the League Cup following a 1-1 draw with Leicester City.
Heres how the sides got on in their last five fixtures:
Liverpool 4-1 Norwich City (09/8)
Newcastle United 0-1 Arsenal (11/8)
Liverpool 2-2 Chelsea *(5-4) (14/8)
Norwich City 3-1 Newcastle United (17/8)
Southampton 1-2 Liverpool (17/8)
Tottenham Hotspur 0-1 Newcastle United (25/8)
Liverpool 3-1 Arsenal (24/8)
Newcastle United 1-1 Leicester City *(2-4) (28/8)
Burnley 0-3 Liverpool (31/8)
Newcastle United 1-1 Watford (31/8)
Things are less bleak at Newcastle as results and performances have taken an upward turn. Nevertheless, they are firm underdogs as they travel to Merseyside to take on the form team in the country.
Liverpool will expect to win with relative ease given their faultless start and the likes of Mane will cause significant issues for the Magpies. Its doubtful whether the visitors will be able to cope with the devastating attacking trident leading the Reds charge.
Prediction: Liverpool 3-1 Newcastle United