Real come into the game in good form, after a crucial derby win last weekend against Atletico Madrid saw them leapfrog their city rivals into second place in La Liga.
Tomorrow:⚽️ @ChampionsLeague Returns:gbeng Liverpool vs. Bayern Ajax vs. Real Madrid Roma vs. Porto Lyon vs. Barcelona gbeng Spurs vs. Dortmund gbeng Man Utd vs. PSG Atlético vs. Juventus Schalke vs. Man City gbeng Bring it on pic.twitter.com/gq59Nbr4b5
— SPORF (@Sporf) February 11, 2019
Ajax are six points behind leaders PSV in the Eredivisie and come into the game off the back of a 1-0 loss to Heracles.
Heres everything you need to know ahead of Wednesdays European encounter.
Where to Watch
When Is Kick Off?
Wednesday 13 February
What Time Is Kick Off?
Where Is It Played?
Johan Cruyff Arena
TV Channel/ Live Stream?
BT Sport 3
Despite being suspended for Real Madrids next match in La Liga, Luka Modric is available for selection against Ajax.
Santiago Solari will be without youngsters Jesus Vallejo, Marcos Llorente and Luca Zidane for the trip to the Dutch capital.
Solaris only injury concern regarding a first-team regular is over the fitness of Isco, who missed the win over Atletico with a back problem.
Ajax have a number of injury worries to contend with themselves, with Hassane Bande, Carel Eiting, Lisandro Magallan and Bruno Varela forming a lengthy list of absentees for the four-time European Cup winners.
Onana; Nissen, De Ligt, Blind, Tagliafico; Schone, Van de Beek, De Jong; Ziyech, Dolberg, Tadic.
Courtois; Carvajal, Varane, Ramos, Marcelo; Modric, Kroos, Casemiro; Bale, Benzema, Vinicius Jr.
Head to Head Record
The two teams, who have won 17 European Cup titles between them, have met on 12 previous occasions.
Real Madrid have the edge in this fixture, winning seven games to Ajaxs four, with a solitary draw. The two teams last met in the group stages of the 2012/13 competition, when Los Merengues recorded a pair of 4-1 victories.
Ajax have not beaten the Spanish giants since the semi finals of the 1972/73 competition, which the Godenzonen went on to win by defeating Juventus 1-0 in the final.
By beating Atletico Madrid in their last fixture, Real stretched their unbeaten run to seven matches in all competitions, a run that has seen them climb to second in La Liga, six points behind leaders Barcelona.
They will undoubtedly be keen to extend this winning run as they chase a historic fourth successive Champions League crown.
Ajax have struggled to maintain any consistency so far in 2019, winning only two of five matches since returning to action in the Eredivisie on 20 January. Although they beat VVV 6-0 in their last home game, Ajax suffered a humiliating 6-2 defeat away to Feyenoord at the end of January.
Here is how each team has performed in their last five matches.
Heracles 1-0 Ajax (9/2)
Atletico Madrid 1-3 Real Madrid (9/2)
Ajax 6-0 VVV (2/2)
Barcelona 1-1 Real Madrid (6/2)
Feyenoord 6-2 Ajax (27/1)
Real Madrid 3-0 Alaves (3/2)
Ajax 3-1 Heerenveen (24/1)
Girona 1-3 Real Madrid (31/1)
Ajax 4-4 Heerenveen (20/1)
Real Madrid 2-0 Sevilla (19/1)
Given that Real Madrid have not lost for almost a month, it is difficult to see anything other than a routine win for Solaris men on Wednesday night.
Ajax should not be taken lightly, but the unpredictable nature of their performances in recent weeks means that Los Blancos, who will be buzzing after a vital derby win, should have more than enough quality to pick apart the hosts.
Prediction: Ajax 0-2 Real Madrid