United fell 2-0 at Arsenal last Sunday as their hosts overtook them for in fourth place in the Premier League. Despite that loss, Solskjær has overseen a remarkable turnaround at Old Trafford, with a string of fine performances and equally positive results igniting their season.
Wolves have enjoyed a superb campaign since returning to the top flight of English football. They occupy seventh position in the league table as things stand, allowing them to focus on their pursuit of what would be a fifth FA Cup trophy.
3. Goalkeeper & Defenders
Sergio Romero (GK) - The Argentine has been a peripheral figure since joining United, having to play second fiddle to the exceptional David de Gea. He has seemed content with cup fixture appearances, looking steady whenever given the opportunity in goal.
Ashley Young (RB) - With Antonio Valencia and Matteo Darmian major doubts for the match, Young is likely to continue in the right-back berth. Though his pace has begun to leave him, the former winger brings experience and composure to the back four.
Victor Lindelof (CB) - The Swedish international was scapegoated for much of Uniteds failures at the beginning of this campaign, but has since turned both his and his teams fortunes around. The centre-back now seems comfortable and confident, flourishing under Solskjærs leadership.
Eric Bailly (CB) - Bailly may be given the nod to allow Chris Smalling a rest after a heavy workload over recent weeks. The former has an abundance of energy and speed that should prove useful when trying to deal with Wolves duo Raul Jimenez and Diogo Jota up front.
Marcos Rojo (LB) - Having recovered from injury, Rojo may be afforded some game time to reach proper match fitness. He will have to be sharp when facing opposing full-back Matt Doherty who has been impressive for the Premier League new boys.
Nemanja Matic (CDM) - Despite Scott McTominay filling in well for the Serbian, no one doubts Matics importance to the Red Devils. He is their anchor in the middle of the park, capable of both beautiful creativity in attack and destructive tackling in defence. His battle with counterpart Ruben Neves could prove pivotal.
Paul Pogba (CM) - He looked a shadow of his former self under Jose Mourinho. Like Lindelof, the Frenchman has been reborn since the appointment of Solskjær and is now beginning to justify the £89m United payed Juventus to acquire his services in 2016.
Fred (CM) - It has been an underwhelming year for the Brazilian. When the entire United side were misfiring, he was one of the players receiving the most criticism. Now the team are back on form, but Fred remains a frustrating figure for the Old Trafford crowds.
Andreas Pereira (CAM) - Injuries to Romelu Lukaku and Alexis Sanchez have given United a bit of a selection headache and although Jesse Lingard is back in training, the last time he was rushed back he was almost immediately re-injured. Pereira has played well enough in the last month to earn enough trust to fill in.
Anthony Martial (ST) - Seemingly on the brink of exiting the three-time European champions earlier in the year, Martial has since become a standout performer. His eye for goal and dribbling abilities have terrorised countless Premier League defences this season.
Marcus Rashford (ST) - Likely to be playing as part of a front two thanks to injuries to Romelu Lukaku and Alexis Sanchez, Rashford will be given a good amount of freedom to roam. United play with a fluidity and ease that suit the England star perfectly, allowing him to get involved in the box as well as to run at defenders out wide.